Methods for Non-Compartmental Pharmacokinetic Analysis With Observations Below the Limit of Quantification
نویسندگان
چکیده
منابع مشابه
Estimating terminal half life by non-compartmental methods with some data below the limit of quantification
In pharmacokinetic studies it occurs more or less frequently that some measurements are reported to be below the limit of quantification. These data are usually discarded in estimating the terminal half-life by non-compartmental methods. We modify this approach to allow for incorporating data below the quantification limit into the analysis. This is achieved by using maximum likelihood methods ...
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ژورنال
عنوان ژورنال: Statistics in Biopharmaceutical Research
سال: 2020
ISSN: 1946-6315
DOI: 10.1080/19466315.2019.1701546